1. Tenerife Airport Disaster (March 27, 1977)
* Fatalities: 583
* Cause: A runway collision between two Boeing 747s (KLM Flight 4805 and Pan Am Flight 1736) in heavy fog due to miscommunication between the flight crews and air traffic control. This remains the deadliest accident in aviation history.
2. Japan Airlines Flight 123 (August 12, 1985)
* Fatalities: 520
* Cause: Structural failure of the aircraft's rear pressure bulkhead, resulting from a faulty repair performed years earlier. This is the deadliest single-aircraft accident.
3. Charkhi Dadri Mid-Air Collision (November 12, 1996)
* Fatalities: 349
* Cause: A mid-air collision between Saudi Arabian Airlines Flight 763 (a Boeing 747) and Kazakhstan Airlines Flight 1907 (an Ilyushin Il-76) over India. The primary cause was a communication error and the Kazakhstan Airlines flight descending below its assigned altitude.
4. Turkish Airlines Flight 981 (March 3, 1974)
* Fatalities: 346
* Cause: A cargo door failure led to an explosive decompression, causing the floor above it to collapse and severing control cables.
5. Air India Flight 182 (June 23, 1985)
* Fatalities: 329
* Cause: A bomb exploded in the cargo hold while the Boeing 747 was en route over the Atlantic Ocean, off the coast of Ireland. It was a terrorist attack.
6. Saudia Flight 163 (August 19, 1980)
* Fatalities: 301
* Cause: A fire broke out in the aft cargo compartment shortly after takeoff. Although the crew successfully made an emergency landing, all occupants died on the ground due to the fire and failure to evacuate the aircraft.
7. Malaysia Airlines Flight 17 (July 17, 2014)
* Fatalities: 298
* Cause: The Boeing 777 was shot down by a surface-to-air missile over eastern Ukraine during a conflict.
8.Iran Air Flight 655 (July 3, 1988)
* Fatalities: 290
* Cause: The Airbus A300 was mistakenly shot down by a missile from the USS Vincennes, a United States Navy guided-missile cruiser, in the Persian Gulf.
9. American Airlines Flight 191 (May 25, 1979)
* Fatalities: 273 (271 on board, 2 on the ground)
* Cause: An engine separated from the wing during takeoff, leading to loss of control and a crash shortly after departing Chicago's O'Hare International Airport.
10. Pan Am Flight 103 (December 21, 1988)
* Fatalities: 270 (259 on board, 11 on the ground)
* Cause: A bomb detonated on board the Boeing 747 while it was flying over Lockerbie, Scotland, a result of a terrorist attack.
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